2-oxo-1-azetidine sulfonic acid derivatives as potent .beta.-lac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540355, C07D205085, A61K 31395

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active

058889981

ABSTRACT:
A compound of formula (I) ##STR1## wherein R.sub.1 is selected from the group consisting of 2-thienyl, 2-furyl, 2-pyrrolyl, 1-methyl-2-pyrrolyl, 2-amino-1-thiazolyl and 5-isothiazolyl;

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patent: 5112968 (1992-05-01), Treuner
Neil S. Isaacs et al., "The Inhibition of Bacterial .beta.-Lactamases by Some Monocyclic .beta.-Lactams", The Journal of Antibiotics, 35(5), 589, 1982.
Karen Bush, et al, "Interaction of Azthreonam and Related Monobactams with .beta.-Lactamases from Gram-Negative Bacteria", Antimicrobial Agents and Chemotherapy, 22(3), 414, 1982.
R.L. Then, "Interaction of Ro 17-2301 (AMA-1080) with .beta.-Lactamases", Chemotherapy (Basel), 30, 398, 1984.
Yuko Sakura et al, "Characteristics of Aztroenonam as a Substrate, Inhibitor and Inducer for .beta.-Lactamases", The Journal of Antibiotics, 43 )4), 403, 1990.

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