2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use

Details 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use

2006-10-10

2006-10-10

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S146000, C548S182000, C548S190000, C544S224000, C544S242000, C544S245000, C544S253000

Reexamination Certificate

active

07119111

ABSTRACT:
Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

REFERENCES:
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patent: WO 00/24744 (2000-05-01), None
patent: WO-01/32649 (2001-05-01), None
patent: WO 01/38312 (2001-05-01), None
patent: WO 01/38315 (2001-05-01), None
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Leeson et al., “4-Amido-2-carboxytetrahydroquinolines. Structure-Activity Relationships for Antagonism at the Glycine Site of the NMDA Receptor”, Journal of Medicinal Chemistry, 35:1954-1968 (1992).
Maccioni et al., “The protein kinase Cdk5: Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology”, European Journal of Biochemistry, 268:1518-1527 (2001).
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Paglini et al., “The role of the Cdk5-p35 kinase in neuronal development”, European Journal of Biochemistry, 268:1528-1533 (2001).
Senderowicz et al., “Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators”, Journal of the National Cancer Institute, 92(5):376-387 (2000).

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