Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-08
2007-05-08
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S412000, C514S414000, C548S465000, C548S469000
Reexamination Certificate
active
10460641
ABSTRACT:
The present invention relates to (2-oxindol-3-ylidenyl)acetic acid derivatives which modulate the activity of protein kinases and are therefore useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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224249 Beilstein, referencing Borshe, Jacobs,Chem. Ber. 47, 354 (1914).
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Borsche, W., “Untersuchungen Uber Isatin Und Verwabdte Verbindungen, I,”Berichte der Deutschen Chemischen Gesellschaft,1914, vol. 47, 354-363.
Borsche, W., “Studies on Isatin and Related Compounds, I, ”Berichte der Deutschen Chemischen Gesellschaft,1914, vol. 47, 354-363 (English translation of above reference).
Inoue, et al., “Total Synthesis of (+)-Surugation,”Tetrahedron Letters,1984, 4407-4410, vol. 25, No. 39.
Okada, et al., “Model Experiments On Surugatoxin Synthesis. An Approach In The Constructions Of The Pentacyclic Ring System,”Tetrathedron Letters,1984, 4403-4407, vol. 25, No. 39.
Okada, et al., “Model Experimentals On Surugatoxin Synthesis V. Construction Of The Dehydrated Surugatoxin Ring System (2),”Yakugaku Zasshi,1985, 375-380, vol. 105.
Tanino, et al., “Model Experimentals On Surugatoxin Synthesis. Vi. Synthesis Of The Ethyl Ester Of The Aglycone Of Surugatoxin And Its Stereoismers,” Yakugaku Zasshi.
Hafez, et al., “Nitriles In Heterocyclic Synthesis. A Novel Syntesis of Spiropyran-4-Ylindolidene Derivatives,”,Journal of Heterocyclic Chemistry,1986, 1375-1378, vol. 23.
Inoue, et al., “Total Synthesis Of (+) —Surugatoxin,”Tetrahedron,1994, 2729-2752, vol. 50, No. 9.
Abdel-Latif, et al., “Heterocycles Synthesis Through Reactions Of Nucleophiles With Acrylonitriles. Part V. Synthesis Of Several New Thiazole And Thiazolo[2,3-A]Pyridine Derivatives,”Polish Journal of Chemistry,1991, 1043-1048, vol. 65.
Abdel-Latif, et al., “Heterocycles Synthesis Through Reactions Of Nucleophiles With Acrylonitriles. Part V. Synthesis Of Several New Thiazole And Thiazolo[2,3-A]Pyridine Derivatives,”Phosphorus, Sulfur , and Silicon,1990, 217-221, vol. 48.
STN English Abstract Beilstein 224249 1914, Borshe et al.
Tang Peng Cho
Wei Chung Chen
Desai Rita
Liptak Vincent P.
Sugen Inc.
Zielinski Bryan C.
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