2-oxa- or -aza-pregnane compounds

Details 2-oxa- or -aza-pregnane compounds 2-oxa- or -aza-pregnane compounds

1986-02-27

1988-11-15

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 77, 549276, A61K 3158, A61K 31585, C07J 7300

Patent

active

047851031

ABSTRACT:
A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing prostatic hypertrophy.

REFERENCES:
patent: 3080381 (1963-03-01), Pappo
patent: 3179658 (1965-04-01), Hirschmann et al.
patent: 3280133 (1966-10-01), Pappo et al.
patent: 3290287 (1966-12-01), Mazur et al.
Applezweig, "Steroid Drugs", McGraw-Hill Book Co., New York, (1962), pp. 340-341, 344, 614-615.
Djerassi, "Steroid Reactions, An Outline for Organic Chemists", Holden-Day, Inc., San Francisco (1963), p. 242.
Nace, et al., J. Organic Chemistry, vol. 31, pp. 2109-2115 (1966).

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