2 (OR 4) Amino 4 (or 2) N-hetero quinazolines

Details 2 (OR 4) Amino 4 (or 2) N-hetero quinazolines 2 (OR 4) Amino 4 (or 2) N-hetero quinazolines

1973-09-05

1976-06-01

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BB, 260287D, 2603261, 424251, C07D23995

Patent

active

039608611

ABSTRACT:
A series of novel 2-amino and 4-aminoquinazoline derivatives have been prepared, including their acid addition salts. These derivatives all possess a single nitrogen-containing benzo-fused heterocyclic ring moiety at either the 4- or 2- positions of the molecule, respectively, with the ring moiety being attached through the nitrogen atom to the aforesaid quinazoline nucleus. Such compounds are useful in therapy as highly potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.

REFERENCES:
patent: 2591545 (1952-04-01), Hepworth
patent: 2945859 (1960-07-01), Hitchings et al.
patent: 3155572 (1964-11-01), Rogers et al.
patent: 3635979 (1972-01-01), Hess
patent: 3769286 (1973-10-01), Hess
patent: 3833584 (1974-09-01), Gabel et al.
Theiling et al., J. Am. Chem. Soc., Nov., 1951 vol. 74, pp. 1834-1836.

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