2- OR 3-Phenyl 1,4-disubstituted phenyl piperazines

Details 2- OR 3-Phenyl 1,4-disubstituted phenyl piperazines 2- OR 3-Phenyl 1,4-disubstituted phenyl piperazines

1975-10-31

1977-03-15

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268MK, 260268H, 260246B, 2602472, 2602475D, 424250, C07D24100, C07D40106

Patent

active

040123898

ABSTRACT:
Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary or cerebral arteries. Examples of such compounds are 1-phenyl (lower) alkyl-2-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-3-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines and their pharmaceutically acceptable acid addition salts. The phenyl ring in 1-position may be substituted by halogen, trifluoro (lower)alkyl, lower alkoxy, or phenyl lower alkoxy; the di-(lower)alkylamino (lower)alkyl group in 4-position may be replaced by piperidino (lower)akyl, morpholino (lower)alkyl, pyrrolidino (lower)alkyl, piperazino (lower)alkyl, or the like mononuclear nitrogen-containing heterocyclically substituted (lower)alkyl.

REFERENCES:
patent: 3935214 (1976-01-01), Zellner

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