2-or 3-dimensional geometric structures

Details 2-or 3-dimensional geometric structures 2-or 3-dimensional geometric structures

1998-05-28

2001-10-30

Houtteman, Scott W. (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C530S324000, C530S334000, C530S338000, C536S018700

Reexamination Certificate

active

06310179

ABSTRACT:

Subject of the present invention is a method for constructing a 2- or 3-dimensional defined polymeric geometric structure from oligomeric elements, such geometric structures as well as the use of nucleic acid analogues in assembling of supramolecular structures of defined form.
Living organisms are build from biomolecules particularly by defined self association of such biomolecules (lipids, protein complexes and DNA double helix). Such supramolecular structures occurring in living organisms are relatively unstable outside of these organisms, because the biomolecules have only limited affinity and are biologically degradable.
Lehn (Science 260, 1762-1763, 1993) describes the use of artificial self assembled complexes from low molecular weight organic molecules and metal ions.
It is further known that holes can be created in Longmuir-Blodget-layers during cluster formation. Such artificial systems are based on the association of uniform molecules having no or small differences.
In nature complex structures are made up from macro molecules of different tertiary structures, based upon uniform basic structures like amino acids and nucleotides. Nucleic acids of complementary sequence form helical chains which can form later in-vivo special structures and networks.
In Angew. Chem. Int. Ed. Engl. 1997, 36, 7, 735-739 a supramolecular structure based on macrocycles is disclosed. In J. Am. Chem. Soc. 1997, 119, 852-853, control of stereochemistry in supramolecular architecture is described.
In J. Vac. Sci. Technol. A 12(4), 1895-1903, there is described the self-assembly of DNA molecules to form a 2-dimensional latice. Such latices are formed using DNA molecules the nucleotide sequence of which is chosen such that four or more of such DNA molecules have a preferred assembly to form a junction. There is explicit explanation in this document how the sequences of the DNA molecules involved has to be chosen. Further there is at least theoretical disclosure how a 3-dimensional object, like a cube, can be created from 6 cyclic DNA molecules. Again, the sequences of the DNA molecules are chosen such that the structure is stabilized and defined by the formation of double stranded DNA along the edges of the cube.
In DE-A-3924454 and U.S. Pat. No. 5,561,071 there is described the use of self-assembled double stranded DNAs for forming conducting elements, for example elements used in electronic chips. The disclosure of this reference is incorporated by reference into the present specification.
The supramolecular structures prepared by self-assembly of DNA have now been found to be so unstable under in vitro conditions that, for example electronic chips prepared by them are not reliable.
In WO 92/20702 there are disclosed purely synthetic oligomeric molecules which are capable of binding to complementary nucleic acids with very high affinity. This can be used for either therapy within the human body or in the diagnosis of nucleic acids in vivo or in vitro. Peptide nucleic acids (PNAs) as described in this reference are characterized by having a non-naturally occurring backbone having attached nucleobases at defined positions, such that these nucleobases can hydrogen bond to the complementary bases on a DNA strand, thus forming a double or triple stranded complex.
It was therefore an object of the present invention to provide high molecular weight supramolecular structures in a more reliable way.
It was an alternative or additional object of the present invention to provide more stable high molecular weight supramolecular structures in a predictable way.
In a further object of the present invention to provide new materials based on supramolecular structures in an intended way, which can be used in computer chips, in roboting, such as robot arms in nanometer scale, in new materials/polymers with conductivity and/or insulator properties.
Subject of the present invention is therefore a method for constructing a 2- or 3-dimensional defined polymeric geometric structures comprising the steps of combining a first oligomeric element having bound recognition elements with a second oligomeric element having bound recognition elements capable of recognizing the recognition elements of said first oligomeric element at binding conditions, wherein said recognition elements are heterocyclic moieties recognizing other recognition elements via hydrogen bonding and wherein said recognition elements of said first and second oligomeric element are bound to spaced defined locations of a peptide bond containing backbone. A further subject of the present invention are such polymeric geometric structures.


REFERENCES:
patent: 5561071 (1996-10-01), Hollenberg et al.
patent: 5714331 (1998-02-01), Buchardt et al.

Affiliated with

Also associated with

Rating

2-or 3-dimensional geometric structures does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-or 3-dimensional geometric structures, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-or 3-dimensional geometric structures will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2576228