2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine inter

Details 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine inter 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine inter

1991-08-13

1992-04-28

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 62, 544105, 540575, C07D26536, C07D41706

Patent

active

051091356

ABSTRACT:
2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of a 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.

REFERENCES:
patent: 4183938 (1990-01-01), Rajagopalan
Kurihara et al., Chemical Abstracts, vol. 70:37748w, (1969).
Brennan and Saxton, Tetrahedron Lett. 26 (14), 1769-1772 (1985).
Tetrahedron 43 (1), 191-205 (1987); Brennan et al.

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