2'-OMe C.sup.AC phosphoramidite and methods for preparation and

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 2531, 536 2534, 536 254, 536 268, C07H 2100, C07H 1906

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058080392

ABSTRACT:
A compound of the general formula ##STR1## wherein R is alkyl of 1 to about 10 carbons and R' is selected from the group consisting of trityl and pixyl, for use in the synthesis of 2'-OMe RNA sequences. Fast cleavage and deprotection of oligonucleotides is facilitated by the use of a reagent comprising methylamine as active component in place of the traditional reagent ammonium hydroxide.

REFERENCES:
patent: 5214135 (1993-05-01), Srivastava et al.
patent: 5348868 (1994-09-01), Reddy et al.
patent: 5428148 (1995-06-01), Reddy et al.
patent: 5525719 (1996-06-01), Srivastava et al.
Agrawal, Sudhir et al. Oligodeoxynucleoside Methylphosphonates: Synthesis and Enzymic Degradation (1987) Tetrahedron Letters, vol. 28, No. 31 pp. 3539-3542.
Beijer, B. et al., Nucleic Acids Research (1990) 18, 5143-5151.
Bhat, U. et al., Nucleoside and Necleotides (1989) 8, 179-183.
Chanteloup, L. and Thuong, N., Tetrahedron Letters (1994) 35, 877-880.
Chattopadhyaya, J. et al., Acta Chem. Scand. (1986) B40, 826-830.
Cotten, M. et al., Nucleic Acids Research (1991) 19, 2629-2635.
Inoue, H. et al., Nucleic Acids Research (1987) 15, 6131-6148.
Inoue H. et al., Nucleic Acids Research Symposium Series (1985) 16, 165-168.
Lamond, I.A. et al. FEWBS Letters (1993) 325, 123-127.
Reddy, M.P. et al., Tetrahedron Lett. (1994) 25, 4311-4314.
Ross, B.S. et al., J. Heterocyclic Chem. (1994) 31, 765-769.
Shimizu, M. et al., FEBS Letters (1992) 302, 155-158.
Sinha, N.D. et al., Nucleic Acids Research (1984) 12, 4538-4557.
Sproat, B.S. et al., Nucleic Acids Research (1990) 18, 41-49.
Vaghefi, M. et al. Nucleosides and Nucleotides (1993) 12, 1007-1013.

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