2'-O, N.sup.6 -disubstituted and 2'-O, N.sup.6, 2-trisubstituted

Details 2'-O, N.sup.6 -disubstituted and 2'-O, N.sup.6, 2-trisubstituted 2'-O, N.sup.6 -disubstituted and 2'-O, N.sup.6, 2-trisubstituted

1994-10-27

1996-07-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2762, 536 2763, A61K 3170, C07H 19167

Patent

active

055345034

ABSTRACT:
Adenosines derivatives of the formula ##STR1## wherein R.sub.1 is allyl, methallyl, straight or branched chain (C.sub.3-7)alkynyl, (C.sub.3-8)cycloalkyl, or phenyl mono- or independently of one another di-substituted by halogen having an atomic number of from 9 to 35, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, or CF.sub.3 ; R.sub.2 is hydrogen or C(.sub.1-4)alkyl, and R.sub.3 is (C.sub.1-4)alkyl, are useful for protecting vascular endothelium, for lowering blood lipid levels, and for treating raised blood pressure.

REFERENCES:
patent: 3471472 (1969-10-01), Thiel et al.
patent: 4843066 (1989-06-01), Yamada et al.
patent: 4962194 (1990-10-01), Bridges
patent: 4985409 (1991-01-01), Yamada et al.
patent: 5032583 (1991-07-01), Evans
Robert F. Bruns, et al. Molecular Pharmacology 29:331-346 (1986).
Kikugawa, et al., J. Med. Chem., vol. 16, No. 4 (1973), pp. 358-364.
Goodman, "Chemical Syntheses and Transformations of Nucleosides," Ch. 2 in Basic Principles in Nucleic Acid Chemistry, vol. 1, P.O.P. Ts'O (ed.), Academic Press, New York, New York, 1974, see pp. 144-145.
Robins et al., "Sugar-Modified N.sup.6 -(3-Methyl-2-butenyl)adenosine Derivatives, N.sup.6 -Benzyl Analogs, and Cytokinin-Related Nucleosides Containing Sulfur or Formycin," Biochemistry, 12(12), 2179-2187 (1973).

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