2-(O-Hydroxyphenyl)-pyrrole and process for its preparation

Details 2-(O-Hydroxyphenyl)-pyrrole and process for its preparation 2-(O-Hydroxyphenyl)-pyrrole and process for its preparation

1979-08-08

1980-12-23

Tovar, Jose

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265L, C07D20744

Patent

active

042409640

ABSTRACT:
2-(o-Hydroxyphenyl)-pyrrole and a process for its preparation, wherein o-benzyloxybenzoic acid allylamide is reacted with phosgene in an inert solvent, the resulting imide-chloride is cyclized in the presence of a strong sterically hindered base and the benzyl protective group is then removed by hydrogenolysis.
2-(o-Hydroxyphenyl)-pyrrole is a valuable intermediate for the synthesis of drugs. In particular, alkylamino-hydroxypropyl ethers thereof can, because of their .beta.-sympatholytic actions, be used for the treatment of coronary cardiac diseases, cardiac arrhythmias and hypertonia.

REFERENCES:
patent: 2489000 (1949-11-01), Valentine, Jr.

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