2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and de

Details 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and de 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and de

1982-08-19

1984-06-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544250, A61K 31505, C07D48704

Patent

active

044553129

ABSTRACT:
2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 has the structural formula ##STR1## Derivatives thereof have the structural formulas ##STR2## where A.sup.+ are alkali metals, monoethanolamine, diethylamine. ##STR3## where R is OH, alkyloxyl C 1-4, NHR.sup.1, where R.sup.1 is H, alkyl C 1-4, phenyl, aralkyl. A are salts of inorganic acids ##STR4## where R is alkyloxyl C 1-4, NHR', where R' is alkyl C 1-4. A method of producing 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof consists in that 2,4-dichloropyrimidine is brought into interaction with anthranilic acid, or a sodium salt of anthranilic acid, or substituted esters, or amides of anthranilic acid in an aqueous medium, or in an organic solvent at a temperature of 90.degree. to 120.degree. C., is kept at this temperature for 1 to 4 hours, and an end product is separated using a conventional method.
A chemotherapeutic antiphlogistic, containing as an acting source 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 or derivatives thereof, and a pharmaceutical basic material.

REFERENCES:
patent: 3598823 (1971-08-01), Hardtmann
patent: 3969506 (1976-07-01), Hardtmann
patent: 4083980 (1978-04-01), Schromm et al.
Journal of Pharmacology and Experimental Therapeutics, Dec. 1962, vol. 138, Number 3, pp. 405-413.
Yanai et al., Chemical Abstracts, vol. 55, 4515b, (1961).

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