2'-O-alkylnucleotides as well as polymers which contain such nuc

Details 2'-O-alkylnucleotides as well as polymers which contain such nuc 2'-O-alkylnucleotides as well as polymers which contain such nuc

1995-01-23

1997-08-19

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 243, 536 261, 536 262, 536 2623, 536 2626, 536 271, 536 2721, 536 284, C12Q 168, C07H 1906, C07H 1916, C07H 2100

Patent

active

056587317

ABSTRACT:
Oligonucleotides having the general formula, ##STR1## in which B denotes an arbitrary nucleobase,

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Anisuzzaman et al. (1990) Polyhedron vol. 9(6):891-892.
Stein et al. (1993) Science, vol 261: 1004-1012.
Wagner et al "Antisense Gene Inhibition by Oligonucleotides . . . " Science 260 (Jun. 1993), pp. 1510-1513.
Gura "Antisense has Growing Pains" Science 270 (Oct. 1995), 575-577.
Milligan et al "Current Concepts in Antisense Drug Design" J. Med. Chem 36 (Jul. 1993), 1923-1937.
Zon et al "Phosphorothioate Oligonucleotides" in Oligonucleotides and their Analogues IRL Press (F. Eckstein Ed) 1991 pp. 87-108.
Sproat "Synthesis of 2'-O-Alkyloligoribonucleotides" in Meth in Molecular Biol. 20 (1993), 115-116 inclusive.
Nucleic Acids Research, (1989) vol. 17, No. 9, pp. 3373-3386.
Nucleic Acids Research, (1987) vol. 15, No. 15, pp. 6131-6148.
Chemical Abstracts, (1991) vol. 114, p. 830. 164721j.
Iribarren, A.M., et al. (1990) Pro. Natl. Acad. Sci. USA vol. 87, pp. 7747-7751.

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