Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-08-19
2000-11-14
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 245, 536 251, 536 2534, 536 267, 536 268, 536 2761, 536 278, 536 2781, 536 285, 536 2853, 514 44, C07H 2102
Patent
active
06147200&
ABSTRACT:
Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to have increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
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Cook Phillip Dan
Fraser Allister S.
Kawasaki Andrew M.
Manoharan Muthiah
Prakash Thazha P.
Crane L. Eric
Geist Gary
ISIS Pharmaceuticals Inc.
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