2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate

Details 2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate 2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate

1989-10-13

1991-08-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 27, 536 28, A61K 3170, C07H 19167, C07H 1916

Patent

active

050397974

ABSTRACT:
The invention is a 2'-O-(4-benzoyl)benzoyl nucleoside 3', 5'-cyclic monophosphate of formula (I) ##STR1## wherein R' is guanine or adenine. Also disclosed are topical pharmaceutical compositions and methods of using them for reducing intraocular pressure.

REFERENCES:
The Journal of Biological Chemistry, vol. 249, No. 11, 1974, pp. 3510-3518, Photoaffinity Labeling of Peptide Hormoine Binding Sites; Richard E. Galardy et al.
The Journal of Biological Chemistry, vol. 257, No. 6, 1982, pp. 2834-2841, Exploring the Adenine Nucleotide Binding Sites on Mitochondrial F.sub.1 -ATPase with a New Photoaffinity Probe, 3'-O-(4-Benzoyl)benzoyl Adenosine 5-Triphosphate; Noreen Williams et al.
The Journal of Biological Chemistry, vol. 261, No. 24 pp. 11374-11377; 1986 3-O-(Benzoyl)benzoylcytidine 5-Triphosphate A Substrate and Photoaffinity Label for CMP-N-Acetyloneuraminic Acid Synthetase; Claudia Abeijon et al.
Analytical Biochemistry, vol. 60, (1974), pp. 163-169; 1,N.sup.6 -Etheno-2-Azadenosine 3'5'-Monophosphate: A New Fluorescent Substrate for Cycle Nucleotide Phosphodiesterase; K. C. Tsou et al.
Science, vol. 177, pp. 279-280; (1972) Fluorescent Modification of Adenosine 3'5'-Monophosphate: Spectroscopic Properties and Activity in Enzyme Systems J. A. Secrist et al.
Biochemistry, vol. 14, No. 17 (1975), pp. 3852-3857; Photoaffinity Labeling of Adenosine 3'5'-Cyclic Monophosphate Binding Sites of Human Red Cell Membranes; Boyd E. Haley.
The Journal of Biological Chemistry, vol. 257, No. 22, pp. 13354-13358, 1982 New Fluorescent Analogs of cAMP and cGMP Available as Substrates for Cyclic Nucleotide Phosphodiesterase; Toshiaki Hiratsuka.
Methods in Enzymology, XLIV, Adenosine', 5'-Cyclic Monophosphate Binding Sites pp. 339-346, (1977).

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