2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric ox

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514471, 514510, 514520, 514522, 514524, 514538, 514562, 514563, 514564, 514617, 514649, 514653, 549 72, 549487, 558414, 558417, 558422, 560 10, 560 17, 560 21, 560 22, 562427, 562431, 562435, 562437, A61K 31135, A61K 31195, A61K 3124, C07C21568

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053627474

ABSTRACT:
2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of vascular smooth muscles or diseases of the cartilage, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, in addition to sickle cell anemia, diabetes, synovitis, chondroarthritis and osteoarthritis by employing these compounds.

REFERENCES:
Kooistra et al, Biochemistry, vol. 17(1978) pp. 345-351.
Gagnon et al, Can. J. Chem., vol. 30(1952) pp. 592-597.

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