2-Nitro-4-(4-pyridinyl) benzoic acids and derivatives

Details 2-Nitro-4-(4-pyridinyl) benzoic acids and derivatives 2-Nitro-4-(4-pyridinyl) benzoic acids and derivatives

1983-07-08

1985-11-12

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546156, 546157, 546161, 546296, 546335, 546345, 544 94, C07D21172, C07D21516, C07D26526

Patent

active

045529663

ABSTRACT:
2-Nitro-4-(4-pyridinyl)benzoic acids, such as 2-nitro-4-(4-pyridinyl)benzoic acid, are prepared by oxidizing the appropriate 4-(4-alkyl-3-nitrophenyl)pyridine with, e.g., potassium permanganate or nitric acid. The products are particularly useful in the preparation of antibacterial 1-alkyl-1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids.

REFERENCES:
patent: 3753993 (1973-08-01), Lesher
patent: 3907808 (1975-09-01), Lesher
patent: 4118557 (1978-10-01), Lesher
Mitscher et al., J. Med. Chem. 1978, vol. 21, No. 5, pp. 485-489.
March, Advanced Organic Chem. 2nd edition, pp. 1096-1097.
Morrison, Organic Chem. p. 441.

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