2-Naphthylacetic acid derivatives

Details 2-Naphthylacetic acid derivatives 2-Naphthylacetic acid derivatives

1976-09-27

1978-06-27

Myers, Jane S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260515R, 260515A, C07C 6336, C07C 6976

Patent

active

040976742

ABSTRACT:
2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

REFERENCES:
patent: 3904682 (1975-09-01), Fried et al.
patent: 4001301 (1977-01-01), Fried et al.
Pala et al, Arzneimittel-Forsch. 16(3), pp. 383-385 (1966).
Marazzi-Wserti, CA 66, p. 114252b (1967).
Oka et al, CA 59, p. 11383 (1963).
Burger, Medicinal Chemistry 3rd Ed., Part 1, pp. 70-72 (1970).
Lecocq, CA 42, p. 7281 (1948).
Jones, JACS 70, pp. 2843-2848 (1948).
Locke et al, JACS 80, pp. 2588-2589 (1958).
Elsevier, Encyclopedia of Organic Chemistry, Series III, vol. 12B, 3354 (1953).

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