2-Naphthyl acetic acid derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260253, 26029362, 260448R, 260469, 2605011, 26050115, 26050117, 2605012, C07C 63592, C07C 6976

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active

039806995

ABSTRACT:
2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

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patent: 3452079 (1969-06-01), Shen et al.
patent: 3506671 (1970-04-01), Kaiser et al.
Buu-Hoi et al. J.C.S. No. 180, pp. 830-832 (1946).
Jones et al., JACS 70, pp. 2843-2848 (1948).
Ormancey et al., Bull. Chim. Soc. No. 179, 962-969 (1955).
Khorana et al., Indian Journal of Pharmacy, pp. 297-301 (1961).
Marazzi-Uberti et al., Chem. Abstracts, vol. 66 (1967), Abs. No. 114252b.

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