2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine

Details 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine

1986-01-08

1989-07-04

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 27, 536 29, C07H 1906, C07H 1910

Patent

active

048452050

ABSTRACT:
The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN with n being an integer between 1 and 4, and X representing a halogen or an amine group. These nucleosides make it possible to prepare sequences of nucleotides usable, in particular, as probes in the field of analyses and biological extractions.

REFERENCES:
patent: 3114751 (1963-12-01), Whetstone
patent: 3308036 (1967-03-01), Nakayama et al.
patent: 3838147 (1974-09-01), Pohlke et al.
patent: 3845035 (1974-10-01), Kampe et al.
patent: 3910883 (1975-10-01), Kikugawa et al.
patent: 3936439 (1976-02-01), Marumoto et al.
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4500707 (1985-02-01), Caruthers et al.
W. L. Sung, "Chemical Conversion of Thymidine into 5-Methyl-2'-deoxycytidine", J.C.S. Chem, Comm., (1981), p. 1089.
J. Davoll, "A Synthesis of Crotonoside", J.A.C.S., vol. 73, (1951), pp. 3174-3176.
K. Itakura et al., "Solid-Phase Synthesis of Polynucleotides", Nucleic Acids Research, (1980), pp. 5473-5489.
Gergen et al., Nucleic Acids Research, vol. 7, (1979), pp. 2115-2137.
Beiter et al., Tetrahedron Letters, vol. 25, No. 19, (1984), pp. 1975-1978.
Chemical Abstracts, vol. 80, (1974), No. 96289.
L. D. Townsend et al., ed. Nucleic Acid Chemistry, (1978), p. 565.

Affiliated with

Also associated with

Rating

2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-853634