Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-12-17
1996-01-16
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2762, 536 2763, 536 277, A61K 3170, C07H 19167
Patent
active
054847745
ABSTRACT:
A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is halogen, trifluoromethyl, cyano, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkylamino or C.sub.1-6 -dialkylamino;
REFERENCES:
patent: 3901876 (1975-08-01), Vorbruggen
Olsson et al., "N.sup.6 -Substituted N-Alkyladenosine-5'-uronamides: Bifunctional Ligands Having Recognition Groups for A1 and A2 Adenosine Receptors," J. Med. Chem., 29(9), 1683-1689 (1986).
Cadogan et al., "On the Formation of Benzenediazonium Chloride in Gomberg-Hey Type Reactions of Diazonium Salts with Bromotrichloromethane, Carbon Tetrachloride, and Chloroform. The Solution of a Long-standing Mechanistic Puzzle," J. Chem. Soc. Chem. Comm., 1976, 851-852.
Vorbrugen et al., "Einfach neue Synthese von N.sup.6 -Substituierten Adenosinen und Adeninen sowie ihrer 2-Amino-- and 2-Hydroxyderivate," Liebigs Ann. Chem., 1976, 745-761.
Nair et al.(I), "Utility of Purinyl Radicals in the Synthesis of Base-Modified Nucleosides and Alkylpurines: 6-Amino Group Replacement by H, Cl, Br, and I," J. Organic Chem., 45(20), 3936-3974 (1980).
Nair et al. (II), "Modification of Nucleic Acid Bases via Radical Intermediates: Synthesis of Dihalogenated Purine Nucleosides", Synthesis, 1982, 832-834.
Koster et al., "Some Improvements in the Synthesis of DNA of Biological Interest," Nucleic Acids Research, Symposium Series No. 7, IRL Press Ltd., 1980, London, U.K., pp. 39-60.
Goodman, "Chemical Syntheses and Transformations of Nucleosides," Ch. 2 in Basic Principles in Nucleic Acid Chemistry, Academic Press, New York, 1974, pp. 94-208, only pp. 153-154 and subsequent pages with reference citations supplied.
Hansen Anker J.
Knutsen Lars J. S.
Lau Jesper
Sheardown Malcolm
Crane L. Eric
Lambiris Elias J.
Novo Nordisk A S
Robinson Douglas W.
Zelson Steve T.
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