Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1977-12-21
1980-07-22
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424180, 536 4, A61K 3171, C07H 1522
Patent
active
042140765
ABSTRACT:
2'-N-substituted fortimicin B and fortimicin B derivatives represented by the formula ##STR1## wherein: R is selected from the group consisting of .beta.-naphthoyl, .gamma.-naphthoyl, .gamma.-naphthyl, (.gamma.-amino-.gamma.-hydroxybutyryl) or 1-(2-amino-4-hydroxybutyl) and R.sub.1 is N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics.
REFERENCES:
patent: 3931400 (1976-01-01), Nara et al.
patent: 3976768 (1976-08-01), Nara et al.
patent: 3985727 (1976-10-01), Daniels
Abbott Laboratories
Brown Johnnie R.
Fato Gildo E.
Niblack Joyce R.
Niblack Robert L.
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