2'-N-Des-.beta.-lysyl antibiotic AX-127B-1 and 4-N-acyl and alky

Details 2'-N-Des-.beta.-lysyl antibiotic AX-127B-1 and 4-N-acyl and alky 2'-N-Des-.beta.-lysyl antibiotic AX-127B-1 and 4-N-acyl and alky

1980-11-10

1982-07-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424181, 435 80, 536 168, A61K 3171, C07H 1522

Patent

active

043383076

ABSTRACT:
2'-N-Des-.beta.-lysyl antibiotic AX-127B-1 and the 4-N-acyl and alkyl derivatives thereof. The compounds are useful as intermediates in the preparation of 3-O-demethyl antibiotic AX-127B-1 and its derivatives. 2'-N-des-.beta.-lysyl antibiotic AX-127B-1 is also useful as a broad spectrum antibacterial agent.

REFERENCES:
patent: 4091032 (1978-05-01), Tadanier et al.
patent: 4187299 (1980-02-01), Post
patent: 4241182 (1980-12-01), Takasawa et al.
patent: 4283529 (1981-08-01), Rosenbrook, Jr.
Tadanier et al., "Carbohydrate Research", vol. 79, pp. 91-102, vol. 85, pp. 61-71, 1980.

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