2-(n-cyanoimino)-thiazolidin-4-one derivatives

Details 2-(n-cyanoimino)-thiazolidin-4-one derivatives 2-(n-cyanoimino)-thiazolidin-4-one derivatives

1995-06-21

1998-05-12

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548189, C07D27734

Patent

active

057507120

ABSTRACT:
A class of novenl compounds represented by the formula (I) ##STR1## wherein R.sub.1 s are the same or different groups and each represents hydrogen atom or alkyl group having 1 to 4 carbon atoms; R.sub.2 is phenyl group, naphthyl group, or either phenyl or naphthyl substituted with at least one hydroxyl, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R.sub.3 is hydrogen atom, alkyl group having 1 to 4 carbon atoms or CH.sub.2 COOR.sub.4 group, in which R.sub.4 is hydrogen atom or alkyl group having 1 to 12 carbon atoms; n is 0 or 1, the configuration of 5-methylene group includes both E-isomer and Z-isomer, providing excepting the case wherein R.sub.1 is hydrogen or methyl, R.sub.2 is 3,5-di-t-butyl-4-hydroxyphenyl, R.sub.3 is hydrogen and n is 0 or pharmacologically acceptable salts thereof when R.sub.3 or R.sub.4 is hydrogen atom
The invention also concerns preparation methods thereof. The present comopounds are useful as prophylactic or therapeutic agent for neuropathy, retinopathy, diabetic cataract, impediment in the kidney as tubulo-nephrosis, all known as complications of chronic diabetes and especially aldose reducing enzyme induced complications

REFERENCES:
patent: 5104888 (1992-04-01), Yoshioka
patent: 5143928 (1992-09-01), Cetenko

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