Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1981-09-21
1984-01-03
Hazel, Blondel
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 168, 536 136, 536 166, C07H 1522
Patent
active
044243448
ABSTRACT:
Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)aprosaminides are new. The 2'-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.
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Kirst Herbert A.
Truedell Brenda A.
Eli Lilly and Company
Harrison Nancy J.
Hazel Blondel
Steinhardt Paul C.
Whale Arthur R.
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