2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 168, 536 136, 536 166, C07H 1522

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044243448

ABSTRACT:
Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)aprosaminides are new. The 2'-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.

REFERENCES:
patent: 4002608 (1977-01-01), Wright
patent: 4136254 (1979-01-01), Nagabhushan et al.
patent: 4166114 (1979-08-01), Igarashi
patent: 4169197 (1979-09-01), Magerlein
patent: 4199570 (1980-04-01), Igarashi et al.
patent: 4200628 (1980-04-01), Igarashi et al.
patent: 4214077 (1980-07-01), Carney et al.
patent: 4230847 (1980-10-01), Nagabhushan
patent: 4283528 (1981-08-01), Daniels et al.
H. A. Kirst, B. A. Truedell, and J. E. Toth, "Control of Site-Specific Substitution, etc.", Tet. Letters, vol. 22, p. 295 (1981, approximately the 1st quarter of the year).
Partial Program of 20th Interscience Conference on Antimicrobial Agents and Chemotherapy (Sep. 23, 1980).
J. Davies and S. O'Connor, "Enzymatic Modification of Aminoglycoside Antibiotics, etc.", Antimicrob. Agents Chemother., 14, 69 (1978).
S. Umezawa et al., Tet. Letters, 4951 (1979).
O. Patil et al., Tet. Letters, 1035 (1978).
T. L. Nagabhushan et al., J. Am. Chem. Soc., 100, 5253 (1978).
T. L. Nagabhushan et al., Abst. 9th Int. Symp. Carbohyd. Chem., paper B36, B37, 1978.
R. E. Carney et al., Abstr. 175th ACS Meeting, Carb. 46, 1978.
G. Patil et al., Tet. Letters, 1031, 1978.

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