2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-

Details 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted- 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-

1982-09-07

1984-08-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 179, 536 181, 536 172, 424180, C07H 1522

Patent

active

044685130

ABSTRACT:
Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)aprosaminides are new. The 2'-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.

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