2'N-Acyl and alkyl-6'-N-alkyl- and 6',6'-di-N-alkyl derivatives

Details 2'N-Acyl and alkyl-6'-N-alkyl- and 6',6'-di-N-alkyl derivatives 2'N-Acyl and alkyl-6'-N-alkyl- and 6',6'-di-N-alkyl derivatives

1977-12-21

1980-04-01

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17R, 536 4, A61K 3171, C07H 1522

Patent

active

041961978

ABSTRACT:
Novel fortimicin derivatives represented by the formula ##STR1## wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; R.sub.1 is loweralkyl, R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics.

REFERENCES:
patent: 3931400 (1976-01-01), Nara et al.
patent: 3976768 (1976-08-01), Nara et al.
patent: 4060682 (1977-11-01), Umezawa et al.

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