2-[(N-2-pyridylcarbamoyl)methyl]saccharin

Details 2-[(N-2-pyridylcarbamoyl)methyl]saccharin 2-[(N-2-pyridylcarbamoyl)methyl]saccharin

1977-08-16

1978-09-26

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260301, 424263, 544 49, C07D41712

Patent

active

041169646

ABSTRACT:
A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, ##STR1## wherein R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl, aryl or a heterocyclic ring selected from the group consisting of pyridyl, substituted-pyridyl, and thiazolyl. Compounds of the formula II have useful anti-inflammatory properties. In addition, they can be used as intermediates in the preparation of known anti-inflammatory agents.

REFERENCES:
patent: 3769292 (1973-10-01), Zinnes et al.
patent: 3828055 (1974-08-01), Zinnes et al.
Fieser & Fieser, Reagents For Organic Synthesis, vol. 1, Wiley Pub., p. 233, 1967.

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