2-(N-(2-aminomethyl)amino)acetic acid derivatives to inhibit adv

Details 2-(N-(2-aminomethyl)amino)acetic acid derivatives to inhibit adv 2-(N-(2-aminomethyl)amino)acetic acid derivatives to inhibit adv

1994-11-10

1996-03-19

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514401, 514408, 514438, 514439, 514461, 514564, A61K 31415, A61K 3140, A61K 3138, A61K 31195

Patent

active

055004369

ABSTRACT:
The invention relates to the use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives of the formula I ##STR1## in which R denotes, for example, phenyl or thienyl, and their pharmacologically acceptable acid addition salts as pharmacological active compounds.

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patent: 5137916 (1992-08-01), Ulrich et al.
patent: 5272176 (1993-12-01), Ulrich et al.
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"The Role of Glycation in Aging and Diabetes Mellitus" M. A. M. von Boekel (Mol. Biol. Rep. 15, 57-64 (1991)).
"Role of Glycation in Aging", A. T. Lee and A. Cerami (Ann. New York Acad. Sci. 663, 63-70 (1992)).
"Glycation and Oxidation: A Role in the Pathogenesis of Atherosclerosis" T. J. Lyons (Am. J. Cardiol. 71 , 26B-31B (1993)).
"Exogenous Advanced Glycosylation End Products Induce Complex" Etc, H. Vlassara et al. (Proc. Natl. Acad. Sci. USA 89, 12043-12047 (1992)).
"Diminished Arterial Elasticity in Diabetes: Association With Fluorescent Advanced Glycosylation End Products In Collagen" K. E. J. Airaksinen et al (Cardiovasc. Res. 27, 942-945 (1993)).

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