Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-09-22
2000-08-08
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142358, 544121, 544130, 544141, 544165, A61K 31535, C07D26530, C07D41306
Patent
active
061002623
ABSTRACT:
The present invention concerns novel (2-morpholinylmethyl)benzamide derivatives having the formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R.sup.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; R.sup.2 is hydrogen, halo or C.sub.1-6 alkylsulfonylamino; R.sup.3 is hydrogen or C.sub.1-6 alkyl; L is a radical of formula R.sup.4 --C(.dbd.O)--Alk-- (a); R.sup.5 --C(.dbd.O)--N(R.sup.6)--Alk-- (b); or R.sup.7 --C(.dbd.O)--O--Alk-- (c); wherein each Alk is independently C.sub.1-12 alkanediyl; R.sup.4 is hydrogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or an optionally substituted heterocyclic ring; R.sup.5 and R.sup.7 each independently are hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or an optionally substituted heterocyclic ring; R.sup.6 is hydrogen or C.sub.1-6 alkyl; and aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents selected from halo, C.sub.1-6 alkyl or C.sub.1-6 alkyloxy. It further relates to pharmaceutical compositions comprising them, processes for preparing said compounds and compositions, and the use thereof as a medicine, in particular in the conditions involving a decreased gastric emptying.
REFERENCES:
Chemical and Pharmaceutical Bulletin, vol. 40, No. 3, 1992, Tokyo JP, pp. 652-660, XP002012408; S. Kato et al.: "Novel benzamides as selective and potent gastrokinetic agents".
Hendrickx Marie-Louise
Van Daele Glenn Kurt Ludo
Van Daele Kurt Godfried Cornelius Emile
Van Daele Peter Jules Victor
Van den Keybus Frans Maria Alfons
Ciambrone Coletti Ellen
Janssen Pharmaceutica NV.
Ramsuer Robert W.
LandOfFree
(2-morpholinylmethyl) benzamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with (2-morpholinylmethyl) benzamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (2-morpholinylmethyl) benzamide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1150378