2'methylidenepyrimidine nucleoside compounds, their use and meth

Details 2'methylidenepyrimidine nucleoside compounds, their use and meth 2'methylidenepyrimidine nucleoside compounds, their use and meth

1993-04-08

1995-03-28

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 285, 536 2852, 536 2855, A61K 3170

Patent

active

054017262

ABSTRACT:
2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, compositions containing one or more of these compounds and methods for production of these compounds are disclosed.
Said compounds and salts thereof exhibit noticeable antitumor activities.

REFERENCES:
patent: 5047520 (1991-09-01), Matsuda et al.
patent: 5183882 (1993-02-01), Sakata et al.
patent: 5300636 (1994-04-01), Matsuda et al.
Takenuki et al., "J. Med. Chem.", 31, 1064-1066 (1988).
"Chemical Abstracts", 110(18) Col. 160409h (1989).
"Chemical and Pharamaceutical Bulletin", 34(4) 1518-1523 (1986).
"Chemical Abstracts", 102(21) Col. 185424g (1985).
"Chemical Abstracts", 104(17) Col. 149328m (1986).

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