2'-methylidenepyrimidine nucleoside compounds

Details 2'-methylidenepyrimidine nucleoside compounds 2'-methylidenepyrimidine nucleoside compounds

1992-01-07

1998-01-06

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 268, 536 275, 536 285, 536 2851, C07H 19073

Patent

active

057056307

ABSTRACT:
2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, anticancer compositions containing one or more of these compounds and methods for production of these compounds.
Said compounds and salts thereof exhibit noticeable antitumor activities and are useful as anticancer agents.

REFERENCES:
patent: 5047520 (1991-09-01), Matsuda et al.
"Chemical and Pharmaceutical Bulletin", 34(4) 1518-1523 (1986).
"Chemical Abstracts", 102(21) Col. 185424g (1985).
"Chemical Abstracts", 104(17) Col. 149328m (1986).
"Chemical Abstracts", 110(18) Col. 160409h (1989).
Takenuki et al., "J. Med. Chem.", 31, 1064-1066 (1988).

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