2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid

Details 2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid 2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid

1992-02-13

1993-07-20

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548413, 548542, C07D20724, C07D20776, A61K 3140

Patent

active

052295230

ABSTRACT:
2-Methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolidines, 2,5-dimethyl-3,4-dihydroxypyrrolidines, their processes of preparation and use are disclosed. 5-Azido-5-deoxyhexulose-1-phosphate compounds and processes of making the same are also disclosed.

REFERENCES:
Paulsen et al., Adv. Carbohydr. Chem. 1968, 23, 115.
Fellows, Chem. Br. 1987, 23, 842.
Truscheit et al., Angew. Chem. Int. Ed. Engl. 1981, 20, 744.
Inouye et al., Tetrahedron 1968, 24, 2125.
Muller, in Biotechnology, Rehm, H. J. et al., eds., VCH Verlagsgesellschaft Weinheim 1985, vol. 4, Chap. 18].
Liu, J. Org. Chem. 1987, 52, 4717.
Anzeveno et al., J. Org. Chem. 1989, 54, 2539.
Yoshikuni et al., J. Pharmacobio-Dyn 1988, 111, 356.
Karpas et al., Proc. Natl. Acad. Sci. 1988, 85, 9229.
Walker et al., Proc. Natl. Acad. Sci. 1987, 84, 8120.
Winkler et al., J. Med. Chem. 1989, 32, 2084.
Humphries, M. J., et al., Cancer Res. 1986, 46, 5215.
Fleet, Chem. Br. 1989, 25, 287.
Bernotas et al., Tetrahedron Lett. 1985, 26, 1123.
Setoi et al., Chem. Pharm. Bull. 1986, 34, 2642.
Legler et al., Carbonhydr. Res. 1984, 128, 61.
Hanesian, Chem. Ind. 1966, 2126.
Ziegler et al., Angew. Chem. Int. Ed. Engl. 1988, 29, 716.
Buchanan et al., J. Chem. Soc. Perkin Trans. 1990, 699.
Fleet et al., J. Chem. Soc. Perkin Trans. 1989, 665.
Dondoni et al., J. Chem. Soc. Chem. Commun. 1990, 854.
Fleet et al., Chem. Lett. 1986, 1051.
Ciufolini et al., J. Am. Chem. Soc. 1989, 111, 3473.
Vasella et al., Helv. Chim. Acta. 1982 65, 1134.
Daigo et al., Chem. Pharm. Bull. 1986, 34, 2243.
Fellows et al., J. C. S. Chem. Comm. 1979, 977.
Saul et al., Arch. Biochem. Biophys. 1983, 221, 593.
Paulsen et al., Chem. Ber. 1867, 100, 802.
Saeki et al., Chem. Pharm. Bull. 1968, 16, 2477.
Kinast et al., Angew. Chem. Int. Ed. Engl. 1981, 20, 805.
Bernotas et al., Tetrahedron Lett. 1984, 25, 165.
Iida, J. Org. Chem. 1987, 52, 3337.
von der Osten et al., J. Am. Chem. Soc. 1989, 111, 3924.
Pederson et al., Heterocycles 1989, 28, 477.
Straub et al., J. Org. Chem. 1990, 55, 3926.
Durrwachter et al., J. Am. Chem. Soc. 1986, 108, 7812.
Durrwachter et al., J. Org. Chem. 1988, 53, 4175.
Bednarski et al., Tetrahedron Lett. 1986, 27, 5807.
Hamana et al., J. Org. Chem. 1987, 52, 5494.
Dale et al., Biochemistry, 1985, 24, 3530.
Pederson et al., J. Org. Chem. 55, 4897 (1990).
Ozaki et al., J. Am. Chem. Soc. 1990, 112, 4970.
Nelson et al., J. Med. Chem., 19:153 (1976).
Weinreb et al., Tetrahedron Lett. 1986, 2099.
Lalegerie et al., Biochemie 1982, 64, 977.
Withers et al., J. Am. Chem. Soc. 1988, 1100, 8551.
Withers et al., J. Am. Chem. Soc. 1990, 112, 5887.
Schweden et al., Arch. Biochem. Biophys., 1986, 248,335.

Affiliated with

Also associated with

Rating

2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1761749