2-Methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid 1-met

Details 2-Methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid 1-met 2-Methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid 1-met

1974-06-26

1976-05-11

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029369, 26029372, 26029373, 26029375, 26029376, 26029382, 26029383, 424267, C07D21146

Patent

active

039563340

ABSTRACT:
Piperidines of the formula ##SPC1##
Wherein R is --CH.sub.2 OH, CO--NR,R.sub.2 in which R.sub.1 and R.sub.2 each are H or alkyl of 1-4 carbon atoms, --NHCH.sub.2 CH.sub.2 OH, --N(CH.sub.2 CH.sub.2 OH).sub.2, --NHCH.sub.2 CH.sub.2 SO.sub.3 H, --NHNH.sub.2 or --NHCH.sub.2 COOH, or --COOR.sub.3 in which R.sub.3 is 3-pyridylmethyl, 2-acetamidoethyl, 1-methyl-4-piperidyl or 2,3-dihydroxypropyl and the physiologically acceptable salts thereof, have cholesterol-level-lowering and triglyceride-level-lowering activity and can be prepared from 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid or a functional derivative thereof by reduction or by reaction with a compound of the formula HZ.

REFERENCES:
patent: 3526632 (1970-09-01), Griot
patent: 3804839 (1974-04-01), Dahm

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