2-methoxyestradiol-induced apoptosis in cancer cells

Details 2-methoxyestradiol-induced apoptosis in cancer cells 2-methoxyestradiol-induced apoptosis in cancer cells

1996-07-30

1999-09-28

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435 6, 435 691, 4351723, 435375, 5303507, A61K 4800, C12N 1579, C12N 510

Patent

active

059588926

ABSTRACT:
The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis of cancer cells following treatment with methoxyestradiol. 2-methoxyestradiol (2-MeOE.sub.2) increase wild-type p53 levels in a human non-small lung cancer cell lines associated with accumulation of cyclin dependent kinase inhibitor p21 WAF1/CIP1. Significant apoptotic cell death occurred after the drug treatment. Thus, 2-MeOE.sub.2 facilitates induction of p53-mediated apoptosis.

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