2-isoxazoline derivative and process for producing the same and

Details 2-isoxazoline derivative and process for producing the same and 2-isoxazoline derivative and process for producing the same and

1999-05-26

2000-01-25

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

564 90, 564 99, 564165, 564185, 564220, 564367, C07C26906

Patent

active

060180692

ABSTRACT:
A purified acid addition salt of a (2S, 3S, 5S)-2,5-diamino-1,6-diphenyl-3-hydroxyhexane, e.g., (2S, 3S, 5S)-2-tert-butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane, is obtained from its mixture, in an arbitrary ratio, with its (2S, 3S, 5R) stereoisomer in the presence of an inorganic or organic acid. The desired (2S, 3S, 5S) acid addition salt may be recovered from the mixture by, for example, recrystallization. These purified acid addition salts are useful as intermediates in the synthesis of medicines such as retrovirus protease inhibitors including human immunodeficiency virus (HIV) protease inhibitors.

REFERENCES:
patent: 5354866 (1994-10-01), Kempf et al.
patent: 5491253 (1996-02-01), Stuk et al.
patent: 5523458 (1996-06-01), Yamasaki et al.

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