2-isocephem and oxacephem derivatives and use as antibacterial a

Details 2-isocephem and oxacephem derivatives and use as antibacterial a 2-isocephem and oxacephem derivatives and use as antibacterial a

1997-10-14

1999-07-06

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540214, 540215, 540200, C07D50148, C07D49804

Patent

active

059199253

ABSTRACT:
Compounds of formula (I) or salts thereof: ##STR1## wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a carboxy protecting group, pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R.sup.4 represents hydrogen or up to four substituents; X is O, S, SO or SO.sub.2 ; Y is O, S, SO or SO.sub.2 ; n is 0 or 1; and m is 1 or 2. The compounds have antibacterial activity. Methods of synthesis of, and pharmaceutical formulations containing, compounds (I) are also described.

REFERENCES:
patent: 4440682 (1984-04-01), Bose et al.
patent: 5578591 (1996-11-01), Burton et al.
Mastalerz et al. J. Med. Chem., 1988, 31, pp. 1190-1196.

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