2-indolinone derivatives as selective histone deacetylase...

Details 2-indolinone derivatives as selective histone deacetylase... 2-indolinone derivatives as selective histone deacetylase...

2011-01-04

2011-01-04

Chu, Yong (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S418000, C514S419000, C548S483000, C548S484000

Reexamination Certificate

active

07863315

ABSTRACT:
Provided herein are isolated compounds of formula I:processes for their preparation and isolation, as well as pharmaceutical compositions which comprise these therapeutic agents, and methods of use therefore the treatment and/or control of conditions associated with or mediated by effects of histone deacetylase.

REFERENCES:
patent: 6541503 (2003-04-01), Davis et al.
patent: 2002/0103192 (2002-08-01), Curtin et al.
patent: 0847992 (1998-06-01), None
patent: WO0118171 (2001-03-01), None
patent: WO0170675 (2001-09-01), None
patent: WO0226696 (2002-04-01), None
STN-12353566-08052010.
de Ruijter, A. J. M., et al., “Histone Deacetylases (HDACs): Characterization of the Classical HDAC Family”, Biochemical Journal, 2003, vol. 370, pp. 737-749.
Marks, P. A. et al., “Histone Deacetylases and Cancer: Causes and Therapies”, Nature Reviews Cancer, 2001, vol. 1, pp. 194-202.
Dokmanovic, M. et al., “Prospects: Histone Deacetylase Inhibitors”, Journal of Cellular Biochemistry, 2005, vol. 96, pp. 293-304.
Herman, D. et al., “Histone Deacetylase Inhibitors Reverse Gene Silencing in Friedreich's Ataxia”, Nature Chemical Biology, 2006, vol. 2, No. 10, pp. 551-559.
Lagger, G. et al., “Essential Function of Histone Deacetylase 1 in Proliferation Control and CDK Inhibitor Repression”, The EMBO Journal, 2002, vol. 21, No. 11, pp. 2672-2681.
Bartl, S. et al., “Identification of Mouse Histone Deacetylase 1 as a Growth Factor-Inducible Gene”, Molecular and Cellular Biology, 1997, vol. 17, No. 9, pp. 5033-5043.
Wilson, A. J. et al., “Histone Deacetylase 3(HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer”, The Journal of Biological Chemistry, 2006, vol. 281, No. 19, pp. 13548-13558.
Sakuma, T. et al., “Aberrant Expression of Histone Deacetylase 6 in Oral Squamous Cell Carcinoma”, International Journal of Oncology, 2006, vol. 29, pp. 117-124.
Avila, A. M. et al., “Trichostatin A Increases SMN Expression and Survival in a Mouse Model of Spinal Muscular Atrophy”, The Journal of Clinical Investigation, 2007, vol. 117, No. 3, pp. 659-671.
Gialitakis, M. et al., “Coordinate Changes of Histone Modifications and HDAC Mobilization Regulate the Induction of MHC Class II Genes by Trichostatin A”, Nucleic Acids Research, 2006, vol. 34, No. 3, pp. 765-772.

Affiliated with

Also associated with

Rating

2-indolinone derivatives as selective histone deacetylase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-indolinone derivatives as selective histone deacetylase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-indolinone derivatives as selective histone deacetylase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2676475