Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-11-25
1985-10-15
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514342, 514343, 514332, 514318, 546278, 546264, 546284, 546283, 544124, C07D40112, A61K 31455, A61K 3144
Patent
active
045475121
ABSTRACT:
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.
REFERENCES:
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patent: 3954782 (1976-05-01), Fleckenstein
patent: 4218452 (1980-08-01), Brown
patent: 4234588 (1980-11-01), Brown
patent: 4238493 (1980-12-01), Roantree et al.
patent: 4307104 (1981-12-01), Roantree
patent: 4469696 (1984-09-01), Rosentreter et al.
Derwent Abstract, 38240C/21, 5/80.
Derwent Abstract, 64650C/37, 9/80.
Jones Martin
Young Rodney C.
Fan Jane T.
Foggio Richard D.
Keps Joan S.
Lourie Alan D.
Smith Kline & French Laboratories Limited
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