2-(Imidazol-1-yl)benzophenones

Details 2-(Imidazol-1-yl)benzophenones 2-(Imidazol-1-yl)benzophenones

1975-04-04

1976-03-02

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240G, 2603409, 260566AE, 260566R, 260578, 260999, C07D23360

Patent

active

039418022

ABSTRACT:
Compounds of the formulae IV and V: ##SPC1##
wherein R.sub.o and R.sub.1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.2 is hydrogen, fluoro, chloro, or trifluoromethyl; wherein R.sub.3 is hydrogen or fluoro with the proviso that R.sub.3 cannot be fluoro, if R.sub.2 is chloro or trifluoromethyl; and wherein R.sub.4 is hydrogen, fluoro, chloro, bromo, trifluoromethyl, or nitro, are obtained by a multi-step reaction from the corresponding .alpha.-(phenyl)-o-toluidine of the formula I ##SPC2##
wherein R.sub.2, R.sub.3, and R.sub.4 are defined as above, by treating I in sequence with an alkyl ester of orthoformic acid the resulting product with 2-alkyl-2-(aminoalkyl)-1,3-dioxolane or a 2-amino-alkanone dialkyl ketal and finally with titanium tetrachloride to obtain compound IV, and oxidizing compound IV to obtain the corresponding compound V.
Compounds IV and V have minor tranquilizing activity which can be utilized to calm mammals or birds. Their more important use, however, is as intermediates in the production of the strongly sedating and tranquilizing imidazolobenzodiazepines.

REFERENCES:
patent: 3526636 (1970-09-01), Houlihan
patent: 3534061 (1970-10-01), Black
patent: 3763178 (1973-10-01), Sulkowski
patent: 3763179 (1973-10-01), Gall

Affiliated with

Also associated with

Rating

2-(Imidazol-1-yl)benzophenones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-(Imidazol-1-yl)benzophenones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-(Imidazol-1-yl)benzophenones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277764