Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1986-04-14
1989-01-17
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544 584, 544 585, 544 587, 544137, 544139, 544143, 544152, 544369, 544370, 544373, 544376, 544379, 546196, 546201, 546202, 546209, 546212, 546214, 548225, 548236, 548336, 548337, 548339, 548343, 548455, 548467, 548492, 548517, 548518, 548525, 548527, 549 57, 549 59, 549 60, 549 61, 549 64, 549 68, 549 69, 549 71, 549467, 549473, 549474, 549479, 549481, 549484, 549486, C07D30754, C07D33338
Patent
active
047988924
ABSTRACT:
The present invention relates to compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR.sub.2 COR.sub.1, --NR.sub.2 CONR.sub.1 R.sub.3, --NR.sub.2 SO.sub.2 R.sub.1, NR.sub.2 SO.sub.2 NR.sub.1 R.sub.3, or --NR.sub.2 COOR.sub.1, wherein R.sub.1, R.sub.2 and R.sub.3 may be alike or different and may be hydrogen, alkyl, alkoxyalkyl cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.1 is not hydrogen when B is --NR.sub.2 SO.sub.2 R.sub.1 or --NR.sub.2 COOR.sub.1, or R.sub.1 and R.sub.3 may together with N form a 5 to 7 membered heterocyclic group and the pharmaceutically acceptable salts thereof. The compounds exhibit beta-adrenergic blocking activity and are also useful in the treatment of glaucoma.
REFERENCES:
patent: 4405642 (1983-09-01), Kam et al.
patent: 4579867 (1986-04-01), Escobar et al.
Kam Sheung T.
Mai Khuong H. X.
Matier William L.
Patil Ghanshyam
E. I. Du Pont de Nemours and Company
Fato Gildo E.
Raymond Richard L.
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