2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives

Details 2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives 2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives

1975-10-15

1977-01-04

Gallagher, R. J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260299, 260302R, C07D27734

Patent

active

040014479

ABSTRACT:
Novel 2-hydroxymethyl-thiazole-5-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms, benzoyl, phenyl optionally substituted with at least one halogen and ##STR2## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Z is selected from the group of phenyl and phenoxy optionally substituted with at least one halogen and R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and alkali metals, alkaline earth metals and aluminum salts, having a marked hypolipemiant activity as well as a clear vasodilatatory activity and which may possess hypocholesterolemiant activity and their preparation.

REFERENCES:
patent: 3897441 (1975-07-01), Edwards

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