2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-t-butylaminoethyl)pyrid

Details 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-t-butylaminoethyl)pyrid 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-t-butylaminoethyl)pyrid

1974-10-09

1976-04-06

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 260297B, C07D21369

Patent

active

039489191

ABSTRACT:
Process for preparing 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-t-butylaminoethyl)pyridine and the acid addition salts thereof which are useful as .beta.-adrenergic agonist bronchodilators in mammals, and the intermediate compounds 2-hydroxymethyl-3-benzyloxypyridine-6-epoxyethane, 2-phenyl-4H-pyrido[3,2-d]-1,3-dioxin-6-epoxyethane and 2,2-disubstituted-4H-pyrido[3,2-d]-1,3-dioxin-6-epoxyethanes.

REFERENCES:
patent: 3253034 (1966-05-01), McLoughlin
patent: 3341594 (1967-09-01), Thoma, et al.
patent: 3700681 (1972-10-01), Barth
Chem. Abstracts, 77:5492m, (1972); Abstract of Japanese Patent 72 03,832, 02021972, Nakanishi et al.

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