Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1988-05-18
1990-03-13
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562431, 549549, 540491, C07C14940
Patent
active
049084690
ABSTRACT:
In general, the present invention provides, in one aspect, a process comprising contacting a 2-Aminothiophenol with an optically active 3-(4-alkyloxyphenyl)glycidic acid acyclic alkyl ester by step(s) under conditions such that an optically active 2-hydroxy-3-(4-alkyloxyphenyl)-3-(2-Aminophenylthio)propionic acid acyclic alkyl ester is prepared. Another aspect comprises the optically active 2-hydroxy-3-(4-alkyloxyphenyl)-3-(2-Aminophenylthio)propionic acid acyclic alkyl ester. A preferred aspect is a process comprising contacting 2-aminothiophenol per se with a 3-(4-methoxyphenyl)glycidic acid methyl ester by step(s) under conditions such that a 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid methyl ester is prepared.
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Sharpless et al., J. Am. Chem. Soc., 102, 5974-5976 (1980).
Bond Robert T.
Marion Laboratories, Inc.
Rudy Christopher John
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