2-Hydroxy-5-phenylazobenzoic acid derivatives and method of trea

Details 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of trea 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of trea

1981-07-08

1983-11-01

Tanenholtz, Alvin E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260207, A61K 31655, C07C10706

Patent

active

044129920

ABSTRACT:
The present invention provides a pharmaceutical composition for treating ulcerative colitis containing at least one compound of the general formula: ##STR1## wherein X is an --SO.sub.2 -- or --CO-- group and R is either an unsubstituted or substituted non-heterocyclic aromatic ring system or is a radical of the general formula --(CH.sub.2).sub.n --Y, in which Y is a hydroxyl group, an unsubstituted or substituted amino group or a carboxylic or sulphonic acid group and n is a whole number of from 1 to 6 and in which one or more hydrogen atoms in the alkylene radical can be replaced by unsubstituted or substituted amino groups or alkyl radicals and in which the --(CH.sub.2).sub.n --Y radical is either attached directly to the nitrogen atom or via a benzene ring; and/or containing at least one ester thereof and/or at least one non-toxic, pharmaceutically acceptable salt thereof, in admixture with a solid or liquid pharmaceutical diluent or carrier. Furthermore, the present invention provides a process for preparing the compounds of the above-given general formulae and also provides a method of treating ulcerative colitis.

REFERENCES:
patent: 3915951 (1975-10-01), Agback et al.
patent: 4045429 (1977-08-01), Agback
Chemical Abstracts, vol. 88, p. 53, abstract No. 69263x, 1978.

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