2-hydroxy-5-(arylazo)-benzene alkanoic acids

Details 2-hydroxy-5-(arylazo)-benzene alkanoic acids 2-hydroxy-5-(arylazo)-benzene alkanoic acids

1985-01-18

1986-12-09

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

534590, 534592, 534774, 534851, 534853, 534887, A61K 31655, C07C10706, C09B 2914, C09B 43136

Patent

active

046280839

ABSTRACT:
The invention relates to new arylazo compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.2 independently of each other represent hydrogen or C.sub.1-3 alkyl, R.sub.3 represents hydrogen, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, carboxy, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkylcarbonyl or a group X--NH--SO.sub.2 --, wherein X represents a heterocyclic ring, R.sub.4 represents hydrogen, halogen or C.sub.1-3 alkyl, and n is the integer 1 or 2, the two groups ##STR2## being the same or different when n is 2, and lactones and salts thereof. The compounds of formula I have a high inhibiting effect on prostaglandin synthetizing and inactivating enzymes and may therefore be used as a drug and anti-fertility agent. The invention also relates to preparation of the compounds of formula I as well as pharmaceutical compositions containing the same.

REFERENCES:
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patent: 3249599 (1966-05-01), May et al.
patent: 3370910 (1968-02-01), Crotte et al.
patent: 3681319 (1972-08-01), Lindberg
patent: 3915951 (1975-10-01), Agback et al.
patent: 4045429 (1977-08-01), Agback
patent: 4153599 (1979-05-01), Rosati
Kornfeld et al, J. Amer. Chem. Soc., vol. 70, pp. 1373 to 1376 (1948).

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