2-hydroxy-3-(aryl-alkanoyl)-benzo[B]thiophenes and compositions

Details 2-hydroxy-3-(aryl-alkanoyl)-benzo[B]thiophenes and compositions 2-hydroxy-3-(aryl-alkanoyl)-benzo[B]thiophenes and compositions

1991-06-27

1992-09-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 52, 549 53, 549 54, 549 55, 549 56, A61K 3138, C07D33364

Patent

active

051478897

ABSTRACT:
Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered heteroaryl radical, wherein the aromatic radical is unsubstituted or is mono- or poly-substituted by lower alkyl, halo-lower alkyl, halogen and/or nitro, and the ring A is unsubstituted or is mono- or poly-substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, halo-lower alkyl, halogen and/or by nitro, can be used, for example, as active ingredients in medicaments.

REFERENCES:
patent: 3558616 (1971-01-01), Brandstrom et al.
patent: 3594478 (1971-07-01), Brandstrom et al.
patent: 4514415 (1985-04-01), Wink et al.
patent: 4663344 (1987-05-01), Durette et al.
N. O. Vesterager et al., Tetrahedron, "Thiophene Chemistry" 29, pp. 321-327 (1973).
K. Sindelar, et al., Chemical Abstracts, 95:7016e, p. 663, abstract of Collect. Czech. Chem. Commun., 1961 46(1), 118-40 (Eng)., (1961).
N. O. Vesterager et al., Chemical Abstracts 78: 135981b p. 355, abstract of Tetrahedron 1973, 29(2), 321-9 (Eng.) (1973).

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