2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for

Details 2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for 2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for

1974-11-22

1976-05-25

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 6988

Patent

active

039593495

ABSTRACT:
A new process for the production of a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4-alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3-methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4-alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much suitable for a commercial practice than the prior art methods.

REFERENCES:
patent: 3259649 (1966-07-01), McClure
patent: 3678093 (1972-07-01), Morita et al.

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