2-Hydrocinnampyl-1,3-cyclopentanediones

Details 2-Hydrocinnampyl-1,3-cyclopentanediones 2-Hydrocinnampyl-1,3-cyclopentanediones

1971-11-26

1977-01-18

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260338, 2603407, 2603409, 260465R, 260465D, 260465E, 260465F, 260465G, 260465H, 260469, 260471R, 260 47C, 260473R, 260475P, 260488CD, 260558A, 260559R, 260568, 260574, 260575, 260577, 260590E, 424278, 424282, 424285, 424300, 424304, 424358, 424309, 424310, 424324, 424330, 424331, C07C 4976, C07C 4980, C07C 4982, C07C 4984

Patent

active

040039366

ABSTRACT:
As new compound, a series of 2-hydrocinnamoyl-1,3-cyclopentanedione derivative of the general formula: ##STR1## WHEREIN Ar stands for a mono-valent aromatic radical, for example, phenyl and 3,4-methylenedioxy-phenyl, substituted or unsubstituted, have been found to have an activity to inhibit the action of tyrosine hydroxylase and to be useful as hypotensive agent. These new compounds may be produced by condensing 2-acetyl-1,3-cyclopentanedione with an aromatic aldehyde of the formula Ar-CHO wherein Ar is as defined, according to Claisen-Schmidt condensation, followed by the hydrogenation of the condensation product obtained, or the new compounds may also be produced by reacting 2-acetyl-1,3-cyclopentanedione with an aromatic halide of the formula Ar-CH.sub.2 X wherein Ar is as defined and X is a halogen, for example, in liquid ammonia and in the presence of an alkali metal amide.

REFERENCES:
patent: 3391165 (1968-07-01), Hughes et al.
patent: 3644502 (1972-02-01), Morin et al.
Tanaka, "Chem. Ab." vol. 73, p. 14487h (1970).

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