2-hydrocarbyl-3,6-dichloropyridines and their preparation

Details 2-hydrocarbyl-3,6-dichloropyridines and their preparation 2-hydrocarbyl-3,6-dichloropyridines and their preparation

1987-02-24

1992-04-21

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546345, 558303, 558368, 558371, 558430, 558432, 558433, 558434, 558440, C07D21361, C07C25330, C07C25503

Patent

active

051069849

ABSTRACT:
2-Hydrocarbyl-3,6-dichloropyridines are prepared from dichloromethyl hydrocarbyl ketones and acrylonitrile in a two-step process involving an addition reaction under basic conditions to form intermediate 1,1-dichloro-3-cyanopropyl hydrocarbyl ketones and a subsequent cyclization reaction in the presence of hydrogen chloride. Thus, 3,6-dichloro-2-methylpyridine is prepared from 1,1-dichloro-2-propanone and acrylonitrile by the formation and further reaction of 4,4-dichloro-5-oxo-hexanenitrile. The intermediates and products are novel compounds useful in the preparation of herbicides and nitrification inhibitors.

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